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MiR-15a can interact with the 3 - untranslated region (UTR) of GPX4 mRNA to negatively regulate the expression of GPX4

In the article, the various functions of glutathione are described as follows: Clinically, glutathione is thought to critical for the following disease and body processes References Mechanism of Action 1-4 Glutathione has many mechanisms in the body to support its role as an antioxidant, a detoxifier, and its involvement in many enzymatic processes including redox reactions

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Taken together, these methodological constraints mean that the robust and consistent epidemiological associations reported in this literature should be regarded as hypothesis-generating signals rather than definitive evidence of a causal neuroprotective effect